The Padres open the season with a four game home stand against the Houston Astros. For some reason (I guess, being that the NL West is odd numbered, five teams, lol) they end the season against an NL Central team, the Pirates.
They have a tough nine game road stand late in September, that could come back to bite them.
The Padres do go to Yankee Stadium in June, I think for the first time since the 1998 World Series.
The Official Site of The San Diego Padres: Schedule: 2008 Padres Sortable Schedule